Selected Journal Publications
Archived Web Publications |
- McKnight, S.L. and Miller, O.L., Jr. (1976). Ultrastructural Patterns of RNA Synthesis During the Early Embryogenesis of Drosophila melanogaster. Cell 8:305-319.
- McKnight, S.L. and Miller, O.L., Jr. (1977). Electron Microscopic Analysis of Chromatin Replication in the Cellular Blastoderm Drosophilia melanogaster Embryo. Cell 12:795-804.
- McKnight, S.L. (1980). The Nucleotide Sequence and Transcript Map of the Herpes Simplex Virus Thymidine Kinase Gene. Nucleic Acids Research 8:5949-5964.
- McKnight, S.L. and Gavis, E.R. (1980). Expression of the Herpes Simplex Virus Thymidine Kinase Gene in Xenopus laevis Oocytes: An Assay for the Study of Deletion Mutants Constructed in vitro. Nucleic Acids Research 8:5931-5948.
- McKnight, S.L. and Kingsbury, R. (1982). Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene. Science 217:316-325.
- Harland, R.M., Weintraub, H. and McKnight, S.L. (1982). Transcription of DNA Injected into Xenopus Oocytes is Influenced by Template Topology. Nature 301:38-43.
- McKnight, S.L. and Tijan, R. (1986). Transcriptional Selectivity of Viral Genes in Mammalian Cells. Cell 46:795-805.
- Johnson, P.F., Landschulz, W.H., Graves, B.J. and McKnight, S.L. (1987). Identification of a Rat Liver Nuclear Protein that Binds to the Enhancer Core Element of Three Animal Viruses. Genes and Dev. 1:133-146.
- Landschulz, W.H., Johnson, P.F. and McKnight, S.L. (1988). The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins. Science 240:1759-1764.
- Landschulz, W.H., Johnson, P.F., Adashi, E.Y., Graves, B.J. and McKnight, S.L. (1988). Isolation of a Recombinant Copy of the Gene Encoding C/EBP. Genes and Dev. 2:786-800.
- Friedman, A.D., Triezenberg, S.J. and McKnight, S.L. (1988). Expression of a Truncated Viral trans-activator in Mammalian Cells Selectively Impedes Lytic Infection by its Cognate Virus. Nature 335:452-454.
- Landshulz, W.H., Johnson, P.F. and McKnight, S.L. (1989). The DNA Binding Domain of C/EBP is Bipartite. Science 243:1681-1688.
- LaMarco, K.L. and McKnight, S.L. (1989). Purification of a Set of Cellular Polypeptides that Bind to the Purine-Rich cis-Regulatory Element of Herpes Simplex Virus Immediate Early Genes. Genes and Dev. 3:1372-1383.
- Vinson, C.R., Sigler, P.B. and McKnight, S.L. (1989). A Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins. Science 246:911-916.
- McKnight, S.L., Lane, M.D. and Gluecksohn-Waelsch, S. (1989). Is CCAAT/Enhancer Binding Protein a Central Regulator of Energy Metabolism? Genes and Dev. 3:2021-2024.
- Umek, R.M., Friedman, A. and McKnight, S.L. (1991). CCAAT/Enhancer Binding Protein: A Component of a Different Switch. Science 251:288-292.
- LaMarco, K., Thompson, C.C., Byers, B.P., Walton, E.M. and McKnight, S.L. (1991). Identification of Ets- and Notch-Related Subunits in GA Binding Protein. Science 253: 789-768.
- Thompson, C.C., Brown, T.A. and McKnight, S.L. (1991). Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex. Science 253:762-768.
- Hou, J., Henzel, W.H., Ho, T.C., Brasseur, M. and McKnight, S.L. (1994). An Interleukin-4-Induced Transcription Factor: IL-4 Stat. Science 265: 1701-1706.
- Batchelor, A.H., Piper, D.E., de la Brousse, F. C., McKnight, S. L. and Wolberger, C. (1998). The Structure of GABPα/β: An ETS Domain-Ankyrin Repeat Heterodimer Bound to DNA. Science 279, 1037-1041.
- Tian, H., Hammer, R.E., Matsumoto, A.M., Russell, D.W. and McKnight, S.L. (1998). The Hypoxia-Responsive Transcription Factor EPAS1 is Essential for Catecholamine Homeostasis and Protection Against Heart Failure During Embryonic Development. Genes & Dev. 12:3320-3324.
- Garcia, J.A., Zhang, D., Estill, S.J., Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R. and McKnight, S.L. (2000). Impaired Cued and Contextual Memory in NPAS2-Deficient Mice. Science 288:2226-2230.
- Reick, M., Garcia, J.A., Dudley, C. and McKnight, S.L. (2001). NPAS2: An Analog of Clock Operative in the Mammalian Forebrain. Science 293:506-509.
- Rutter, J., Garcia, J.A., Dudley, C. and McKnight, S.L. (2001) . Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors. Science 293:510-514.
- Rutter, J., Michnoff, C.H., Harper, S.M., Gardner, K.H. and McKnight, S.L. (2001). PAS Kinase: An Evolutionarily Conserved PAS Domain-Regulated Serine/Threonine Kinase. Proc. Natl. Acad. Sci. 98:8991-8996.
- Bruick, R., McKnight, S.L. (2001). A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF. Science 294:1337-1340.
- Rutter, J., Reick, M. and McKnight, S.L. (2002). Metabolism and the Control of Circadian Rhythm. Annu. Rev. Biochem. 71:307-331.
- Rutter, J., Probst, B.L. and McKnight, S.L. (2002). Coordinate Regulation of Sugar Flux and Translation by PAS Kinase. Cell 111:17-28.
- Dioum, E.M., Rutter, J., Tuckerman, J.R., Gonzalez, G., Gilles-Gonzalez, M.-A. and McKnight, S.L. (2002). NPAS2: A Gas-Responsive Transcription Factor. Science 298:2385-2387.
- Dudley, C.A, Erbel-Sieler, C., Estill, S.J., Reick, M., Franken, P., Pitts, S. and McKnight, S.L. (2003). Altered Patterns of Sleep and Behavioral Adaptability in NPAS2-Deficient Mice. Science 301:379-383.
- Erbel-Sieler, C., Dudley, C., Zhou, Y., Wu, X., Estill, S.J., Han, T., Diaz-Arrastia, R., Brunskill, E.W., Potter, S.S., and McKnight, S.L. (2004). Behavioral and Regulatory Abnormalities in Mice Deficient in the NPAS1 and NPAS3 Transcription Factors. Proc. Natl. Acad. Sci. 101:13648-13653.
- Wu, X., Alexander, P., He, Y., Kikkawa, M., Vogel, and P., McKnight, S.L (2005). Mammalian Sprouty Proteins Assemble into Large, Monodisperse Particles Having the Properties of Intracellular Nanobatteries. Proc. Natl. Acad. Sci. 102:14058-14062.
- Pieper, A., Wu, X., Han, T., Estill, S.J., Dang, Q., Wu, L., Reece-Fincanon, S., Dudley, C., Richardson, J., Brat, Daniel, and McKnight, S.L. (2005) The Neuronal PAS Domain Protein 3 Transcription Factor Controls FGF-mediated Adult Hippocampal Neurogenesis in Mice. Proc. Natl. Acad. Sci. 102:14052-14057.
- Tu, B.P., Kudlicki, A., Rowicka, M., and McKnight, S.L. (2005). Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes. Science 310:1152-1158.
- Franken, P., Dudley, C.A., Estill, S.J. Barakat, M., Thomason, R., O’Harra, B.F., and McKnight, S.L. (2006). NPAS2 as a Transcriptional Regulator of Non-rapid Eye Movement Sleep: Genetype and Sex Interactions. Proc. Natl. Acad. Sci. 103:7118-7123.
- Tu, B.P. and McKnight, S.L. (2006). Metabolic Cycles as an Underlying Basis of Biological Oscillations. Nat. Rev. Mol. Cell Biol., 7(9): 696-701.
- Williams, N.S., Burgett, A.W.G., Atkins, A.S., Wang, X., Harran, P.G., and McKnight, S.L. (2007) Therapeutic Anticancer Efficacy of a Synthetic Diazonamide Analog in the Absence of Overt Toxicity. Proc. Natl. Acad. Sci. 104:2074-2079.
- Chen, Z., Odstrcil, E.A., Tu, B.P., and McKnight, S.L. (2007). Restriction of DNA Replication to the Reductive Phase of the Metabolic Cycle Protects Genome Integrity. Science, 316:1916-1919.
- Tu, B.P., Mohler, R.E., Liu, J.C., Dombek, K.M., Young, E.T., Synovec, R.E., and McKnight, S.L. (2007). Cycle Changes in Metabolic State During the Life of a Yeast Cell. Proc. Natl. Acad. Sci. 104:16886-16891.
- Chen, Z., and McKnight, S.L. (2007). A Conserved DNA Damage Response Pathway Responsible for Coupling the Cell Division Cycle to the Circadian and Metabolic Cycles. Cell Cycle 6:2906-2912.
- Wang, J., Alexander, P., Wu, L., Hammer, R., Cleaver, O., and McKnight, S.L. (2009). Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism. Science 325:435-439.
- Tu, B.P. and McKnight, S.L. (2009). Evidence of Carbon Monoxide-Mediated Phase Advancement of the Yeast Metabolic Cycle. Proc. Natl. Acad. Sci. 106:14293-14296.
- Pieper, A.A., Xie, S., Capota, E., Estill, S.J., Zhong, J., Long, J.M., Becker, G.L., Huntington, P., Goldman, S.E., Shen, C.H., Capota, M., Britt, J.K., Hsieh, J., De Brabander, J., Ready, J.M. and McKnight, S.L. (2010). Discovery of a Proneurogenic, Neuroprotective Chemical. Cell 142:1-13.
- McKnight, S.L. (2010). On Getting There from Here (Editorial Essay). Science 330:1338-1339.
- Alexander, P. B., Wang, J. and McKnight, S. L. (2011). Targeted Killing of a Mammalian Cell Based Upon its Specialized Metabolic State. Proc. Nat. Acad. Sci. 108:15828-15833.
- Kato, M., Han, T.W., Xie, S., Shi, K., Du, X., Wu, L.C., Mirzaei, H., Goldsmith, E.J., Longgood, J., Pei, J., Grishin, N.V., Frantz, D.E., Schneider, J.W., Chen, S., Li, L., Sawaya, M.R., Eisenberg, D., Tycko, R. and McKnight, S.L. (2012). Cell-Free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels. Cell 149:753-767.
- Han, T. W., Kato, M., Xie, S., Wu, L. C., Mirzaei, H., Pei, J., Chen, M., Xie, Y., Allen, J., Xiao, G. and McKnight, S. L. (2012). Cell-Free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies. Cell 149:768-779.
- De Jesus-Cortes, H,. Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J., Melito, L. M., Wang, G., Williams, N. S., Ready, J. M., McKnight, S. L. and Pieper, A. A. (2012). Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc. Nat. Acad. Sci. 109: 17010-17015.
- Tesla, R., Wolf, H. P., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S., Starwalt, R., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., McKnight, S.L. and Pieper, A. A. (2012). Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc. Nat. Acad. Sci. 109:17016-17021.
- McKnight, S.L. (2012). Pure Genes, Pure Genius (Editorial Essay). Cell 150:1100-1102.
- Kaelin, W.G., Jr. and McKnight, S.L. (2013). Influence of Metabolism on Epigenetics and Disease (Review). Cell 153:56-59.
- Kwon, I., Kato, M., Xiang, S., Wu, L., Theodoropoulos, P., Mirzaei, H., Han, T., Xie, S., Corden, J.L., and McKnight, S.L. (2013). Phosphorylation-regulated Binding of RNA Polymerase II to Fibrous Polymers of Low Complexity Sequences. Cell 155:1049-1060.
- Pieper, A. A., McKnight, S.L. and Ready, J. M. (2014). P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem.Soc.Rev. DOI: 10.1039/C3CS60448A
- Kwon, I., Xiang, S., Kato, M., Wu, L., Theodoropoulos, P., Wang, T., Kim, J., Yun,Y., Xie, Y. and McKnight, S.L. (2014). Poly-dipeptides encoded by the C9ORF72 repeats bind nucleoli, impede RNA biogenesis, and kill cells. Science 345:1139-1145.
- Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., and McKnight, S.L. (2014). P7C3 Neuroprotective Chemicals Function by Activating the Rate-limiting Enzyme in NAD Salvage. Cell 158:1324-1334.
- Yin, T.C., Britt, J.K., De Jesus-Cortes, H., Lu, Y., Genova, R.M., Kahn, M.Z., Vorhees, J.R., Shao, J., Katzman, A.C., Huntingon, P.J., Wassink, C., McKaniel, L., Newell, E.A., Ducta, L.M., Naidoo, J., Cui, H., Bassuk, A.G., Harper, M.M., McKnight, S.L., Ready, J.M., and Pieper, A.A. (2014). P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury. Cell Reports 8:1-10.
- Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. and Tu, B. P. (2014). Acetate Dependence of Tumors. Cell 159:1591-1602.
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